Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice
| Autor: | Mohamed Elsaed Ebada, David A. Kendall, Marie-Christine Pardon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Volition medicine.medical_specialty Physical exercise Running 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Glucocorticoid receptor Hormone Antagonists Receptors Glucocorticoid Corticosterone Dopamine receptor D3 Memory Internal medicine Dopamine receptor D2 C57BL/6J mice Dopamine D2/D3 receptors medicine Animals Enzyme Inhibitors Glucocorticoid receptors Receptor Nootropic Agents Motivation Metyrapone Dose-Response Relationship Drug Receptors Dopamine D2 Voluntary wheel running Receptors Dopamine D3 Mice Inbred C57BL Mifepristone 030104 developmental biology Endocrinology chemistry Dopamine Antagonists Sulpiride Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural brain research. 311 |
| ISSN: | 1872-7549 0166-4328 |
| Popis: | Physical exercise can improve cognition but whether this is related to motivation levels is unknown. Voluntary wheel running is a rewarding activity proposed as a model of motivation to exercise. To question the potential effects of exercise motivation on subsequent behaviour, we used a pharmacological approach targeting some reward mechanisms. The stress hormone corticosterone has rewarding effects mediated by activation of low affinity glucocorticoid receptors (GR). To investigate whether corticosterone synthesis motivates exercise via activation of GRs and subsequently, impacts on behaviour, we treated C57BL/6J mice acutely with the inhibitor of corticosterone synthesis metyrapone (35 mg/kg) or repeatedly with the GR antagonist mifepristone (30 mg/kg) prior to 1-h running wheel sessions. To investigate whether reducing motivation to exercise impacts on behaviour, we antagonised running-induced dopamine D2/D3 receptors activation with sulpiride (25 or 50 mg/kg) and assessed locomotor, anxietyrelated and memory performance after 20 running sessions over 4 weeks. We found that corticosterone synthesis contributes to running levels, but the maintenance of running behaviour was not mediated by activation of GRs. Intermittent exercise was not associated with changes in behavioural or cognitive performance. The persistent reduction in exercise levels triggered by sulpiride also had limited impact on behavioural performance, although the level of performance for some behaviours was related to the level of exercise. Altogether, these findings indicate that corticosterone and dopamine D2/D3 receptor activation contribute to the motivation for wheel running, but suggest that motivation for exercise is not a sufficient factor to alter behaviour in healthy mice. |
| Databáze: | OpenAIRE |
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