Chondroblastoma: An Update
| Autor: | Lisa M. DiFrancesco, Wenqian Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Chondrosarcoma Bone Neoplasms Biology Chondroblastoma Bone and Bones Pathology and Forensic Medicine Lesion Diagnosis Differential Histones 03 medical and health sciences 0302 clinical medicine Chondroblastic Osteosarcoma Chloride Channels medicine Humans Anoctamin-1 Osteosarcoma Cartilage SOX9 Transcription Factor General Medicine Aneurysmal bone cyst Anatomy medicine.disease Neoplasm Proteins Medical Laboratory Technology H3F3B 030104 developmental biology Primary bone medicine.anatomical_structure Amino Acid Substitution Giant cell 030220 oncology & carcinogenesis Mutation medicine.symptom Neoplasm Recurrence Local |
| Zdroj: | Archives of pathologylaboratory medicine. 141(6) |
| ISSN: | 1543-2165 |
| Popis: | Chondroblastoma is a rare primary bone tumor of young people that typically arises in the ends of the long bones. Radiologic investigations show a small, circumscribed, lytic lesion. The tumor is characterized histologically by the proliferation of chondroblasts along with areas of mature cartilage, giant cells, and occasionally, secondary aneurysmal bone cyst formation. Chondroblastoma, however, may also present with atypical features, such as prominent hemosiderin deposition, numerous giant cells, or the presence of a large aneurysmal bone cyst component. Malignant entities such as clear cell chondrosarcoma and chondroblastic osteosarcoma must also be considered. Recently, immunohistochemical stains such as DOG1 and SOX9 have been described in chondroblastoma, and K36M mutations in either the H3F3A or H3F3B genes have also been identified. While generally regarded as a benign entity, chondroblastoma manifests an intermediate type of behavior, given its ability to recur locally, and rarely, metastasize. |
| Databáze: | OpenAIRE |
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