Development of novel in vitro human digestion systems for screening the bioavailability and digestibility of foods
Autor: | Myung-Sub Chung, Sun Jin Hur, Seung-Jae Lee, Seung Yuan Lee |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Lactobacillus casei
Antioxidant Bioavailability medicine.medical_treatment Medicine (miscellaneous) chemistry.chemical_compound Rutin 0404 agricultural biotechnology Chlorogenic acid Gastrointestinal tract medicine TX341-641 Nutrition and Dietetics biology Nutrition. Foods and food supply Enterobacter bacteria 04 agricultural and veterinary sciences In vitro human digestion biology.organism_classification 040401 food science Small intestine Enzymes medicine.anatomical_structure chemistry Biochemistry Digestion Quercetin Food Science |
Zdroj: | Journal of Functional Foods, Vol 22, Iss, Pp 113-121 (2016) |
ISSN: | 1756-4646 |
Popis: | The in vitro models employed have included all steps involved in digestion upon passage through the mouth, stomach, small intestine, and the colon. Importantly, enterobacter bacteria (Escherichia coli and Lactobacillus casei) are included to simulate the colon step. After in vitro human digestion in the small and large intestines, the antioxidant activity of rutin increased dramatically, whereas the antioxidant activity was not influenced by digestion in the mouth or the stomach. Before in vitro human digestion, the antioxidant activity of quercetin and chlorogenic acid was increased, and after in vitro human digestion in the small intestine and large intestines (with enterobacteria), the antioxidant activity of quercetin increased although enterobacteria did not influence the antioxidant activity. However, the antioxidant activity of chlorogenic acid was not influenced by in vitro human digestion in the small intestine and large intestines (with enterobacteria). This study provides data supporting an alternative to the use of animals and humans for rapid screening of food digestibility and bioavailability. |
Databáze: | OpenAIRE |
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