GENETIC DIVERSITY AND STRUCTURE OF AFRICAN PLASMODIUM FALCIPARUM POPULATIONS IN URBAN AND RURAL AREAS
| Autor: | Christophe Rogier, Serge-Brice Assi, Housem Bouchiba, Marie-Claire Henry, Bruno Pradines, Eric Garnotel, Thierry Fusai, Mohamed Ali Kamil, Odile Puijalon, Patrick Durand, Eric Adehossi, Hervé Bogreau, François Renaud, Philippe Parola, Boubacar Wade |
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| Rok vydání: | 2006 |
| Předmět: |
Rural Population
Linkage disequilibrium Genotype Urban Population Plasmodium falciparum STRUCTURE DE POPULATION Polymerase Chain Reaction Linkage Disequilibrium Virology parasitic diseases ETUDE COMPARATIVE TECHNIQUE PCR medicine Animals Humans MARQUEUR MOLECULAIRE Genetic variability Malaria Falciparum PARASITE VARIABILITE GENETIQUE MILIEU URBAIN DNA Primers Genetic diversity Geography biology Ecology Genetic Variation PALUDISME DIVERSITE GENETIQUE biology.organism_classification medicine.disease GENOTYPE Infectious Diseases Africa VARIATION SPATIALE POLYMORPHISME GENETIQUE Biological dispersal Parasitology ANALYSE GENETIQUE Rural area MILIEU RURAL Malaria Microsatellite Repeats |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | The genetic variability and population structure of Plasmodium falciparum are key factors in malaria control strategies. Studies have suggested no P. falciparum population structure although linkage disequilibrium was observed in some African areas. We have assessed length polymorphism at 6-22 microsatellites in four urban and rural sites (Djibouti, Dakar, Niamey, and Zouan-Hounien, n = 240 blood samples). Results have shown a P. falciparum population structure in Africa (Fst = 0.17-0.24), lower genetic diversity in Djibouti (He = 0.53) than in the other sites (He = 0.73-0.76), and 3) significant linkage disequilibrium in Djibouti. These results could be related to geographic isolation and low flow of parasites between sites. They also suggest a potential effect of rural suburbs to generate genetic diversity in towns. This could affect the dispersal of selected drug resistance and should be considered when adapting urban malaria control strategies. |
| Databáze: | OpenAIRE |
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