Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig)
| Autor: | Bernard Marchand, Claude Benezra, Georges Ducombs, Pierre Martin, Pierre Barbier, Jean Foussereau |
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| Rok vydání: | 1982 |
| Předmět: |
Chemical Phenomena
Stereochemistry Guinea Pigs Dermatology Dermatitis Contact Dermatitis Atopic Guinea pig Drug Hypersensitivity chemistry.chemical_compound In vivo Phenyl salicylate Nucleophilic substitution medicine Structure–activity relationship Animals Humans Allergic contact dermatitis Sensitization Aryl General Medicine Patch Tests medicine.disease Salicylates Chemistry medicine.anatomical_structure chemistry Cheilitis Female Dermatologic Agents |
| Zdroj: | Archives of dermatological research. 272(1-2) |
| ISSN: | 0340-3696 |
| Popis: | Patients sensitive to phenyl salicylate (salol) were patch-tested to several aryl salicylates. The most powerful derivative was p-nitrophenyl salicylate (compound 5). This can be explained by an unusually good interaction with protein (nucleophilic substitution on the carboxyl carbon). All these results were confirmed by experimental sensitization of guinea pigs to salol and cross-reaction to substituted salols. The results are in line with current theory of allergic contact dermatitis, i.e., an in vivo formation of a hapten-protein conjugate. |
| Databáze: | OpenAIRE |
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