Association of SP-B gene 9306 A/G polymorphism (rs7316) and risk of RDS
| Autor: | Neda Fatahi, Tahereh Esmaeilnia Shirvani, Nikoo Niknafs, Nasrin Ghasemi-Fakhr, Javad Tavakkoly-Bazzaz, Fatemeh Nayeri, Amir Kamal Hardani, Elaheh Amini, Roya Taheritafti, Hosein Dalili, Mamak Shariat, Majid Kalani, Ali Rashidi-Nezhad, Ramin Rashidi-Nezhad, Mohsen Ghadami |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pulmonary disease macromolecular substances Iran 03 medical and health sciences 0302 clinical medicine Humans Medicine Genetic Predisposition to Disease Pulmonary surfactant-associated protein B 030212 general & internal medicine Gene Genetics Respiratory Distress Syndrome Newborn Polymorphism Genetic Pulmonary Surfactant-Associated Protein B Respiratory distress business.industry Infant Newborn Case-control study Obstetrics and Gynecology Infant newborn Case-Control Studies 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Immunology Female RESPIRATORY DISTRESS SYNDROME NEWBORN business Infant Premature |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 31:2965-2970 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2017.1359829 |
| Popis: | Respiratory distress syndrome (RDS) is a severe pulmonary disease predominantly affects preterm newborns. Polymorphisms of surfactant-protein genes have been mostly evaluated as the candidate contributors in genetics of RDS. However the results are divers in different studies. We aimed at investigating the association of surfactant protein B (SPB) gene 9306 A/G polymorphism (rs7316) with RDS development.Three hundred and eighty newborns with gestational age of less than 34 weeks were included in a multicenter case-control study. Respiratory distress (RD) was scored according to Downes' scoring system. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping.One hundred and eighty-four neonates showed RDS and 196 did not. Gestational age (GA) was significantly lower in the RDS group compared with the controls. AA genotype and A allele were found more frequently in the RDS group than the controls (96.2% versus 63.8% and 98.1% versus 80.6%, respectively) (p =.0001).This is the first report of association of SFTPB rs7316 polymorphism with RDS development in Iranian newborns. The current study suggests that GA28-weeks is the most important factor in predisposition to RDS. Genetic background in terms of SP-B gene might be involved in predisposition to RDS in premature neonates. |
| Databáze: | OpenAIRE |
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