Simultaneous occurrence of myelodysplastic syndrome and monoclonal B lymphocytes with a different clonal origin
| Autor: | Johan Billiet, Arnold Criel, Andries Louwagie, M. Van Leeuwen, B. Cauwelier, E. De Laere, F. Nollet |
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| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
CD34 Trisomy Biology CD19 medicine Humans Cell Lineage Aged B-Lymphocytes medicine.diagnostic_test Chromosomes Human Pair 13 Hematology medicine.disease Flow Cytometry Virology Molecular biology Lymphoma Clone Cells medicine.anatomical_structure Cell Transformation Neoplastic Oncology Myelodysplastic Syndromes Monoclonal Cytogenetic Analysis biology.protein Female Bone marrow Stem cell Fluorescence in situ hybridization |
| Zdroj: | Leukemialymphoma. 43(1) |
| ISSN: | 1042-8194 |
| Popis: | Bone marrow and peripheral blood from a myelodysplastic syndrome patient with trisomy 13 and monoclonal B lymphocytes (without evidence of systemic lymphoma) were investigated for clonal lymphoid lineage involvement using interphase fluorescence in situ hybridization (FISH) and X-chromosome inactivation assay (HUMARA) on CD19+ and CD34+ sorted cells. Trisomy 13 was detected in 55% of CD34+ cells and in 5.5% of CD19+ cells, the latter being comparable to the negative control specimen. X-chromosome inactivation showed both CD34+ and CD19+ cells to be monoclonal, though their inactivated X-chromosome was different. The results strongly suggested that both populations of CD34+ and CD19+ cells have originated from a different progenitor stem cell. |
| Databáze: | OpenAIRE |
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