Effect of Insulin Analogs on the Decline of Hemoglobin in Diabetic Patients with Nephropathy
| Autor: | E. Collenberg, J. Möcks, C. Hasslacher |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin analog Kidney Function Tests Nephropathy Hemoglobins Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents Insulin Diabetic Nephropathies Erythropoietin biology business.industry General Medicine medicine.disease Insulin receptor Creatinine biology.protein Erythropoiesis Female business medicine.drug Kidney disease |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 118:341-345 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1241826 |
| Popis: | Aim: Decrease of hemoglobin occurs in diabetic patients with nephropathy earlier than in non-diabetic patients, probably due to impaired synthesis of erythropoietin (EPO). Apart from EPO, insulin also stimulates erythropoiesis. We investigate whether there are differences between human insulin and insulin analogs in respect of their erythropoiesis stimulating effect. Patients and Methods: Hemoglobin concentration and other factors which may influence hemoglobin levels were analyzed retrospectively in 203 type 1 diabetic patients with various degrees of kidney function. Eighty-six patients were treated with human insulin and 117 patients received an insulin analog. Results: Hemoglobin concentration did not differ in patients with normal renal function (creatinine clearance (CCL) >90ml/min) treated with human insulin or insulin analogs. In patients with impaired renal function (CCL |
| Databáze: | OpenAIRE |
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