Metabolic Links between Plasma Cell Survival, Secretion, and Stress
| Autor: | Deepta Bhattacharya, Wing Y. Lam |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Protein Folding Glycosylation Cell Survival Plasma Cells Immunology Biology Plasma cell Endoplasmic Reticulum Antibodies Article 03 medical and health sciences chemistry.chemical_compound Stress Physiological Immunity medicine Animals Humans Immunology and Allergy Secretion Endoplasmic reticulum Immunity Humoral 030104 developmental biology medicine.anatomical_structure chemistry Biochemistry Antibody Formation Humoral immunity biology.protein Antibody Biogenesis |
| Zdroj: | Trends in Immunology. 39:19-27 |
| ISSN: | 1471-4906 |
| DOI: | 10.1016/j.it.2017.08.007 |
| Popis: | Humoral immunity is generated and maintained by antigen-specific antibodies that counter infectious pathogens. Plasma cells are the major producers of antibodies during and after infections, with each plasma cell producing some thousands of antibody molecules per second. This magnitude of secretion requires enormous quantities of amino acids and glycosylation sugars to properly build and fold antibodies, biosynthetic substrates to fuel endoplasmic reticulum (ER) biogenesis, and additional carbon sources to generate energy. Many of these processes are likely to be linked, thereby affording possibilities to improve vaccine design and to develop new therapies for autoimmunity. Here, we review aspects of plasma cell biology with an emphasis on recent studies and the relationships between intermediary metabolism, antibody production, and lifespan. |
| Databáze: | OpenAIRE |
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