Anti-Müllerian Hormone Predicts Menopause: A Long-Term Follow-Up Study in Normoovulatory Women
| Autor: | B. C. J. M. Fauser, Frank J.M. Broekmans, F. H. De Jong, Joop S.E. Laven, Marinus J.C. Eijkemans, E.R. te Velde, A. P. N. Themmen, G.J. Scheffer, A. de Vet, I.A.L.M. van Rooij, Simone L. Broer |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Anti-Mullerian Hormone Ovulation Infertility endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Psychological intervention Context (language use) Disease Biochemistry Young Adult Endocrinology Predictive Value of Tests Surveys and Questionnaires Internal medicine medicine Humans Prospective Studies Ovarian reserve biology business.industry Biochemistry (medical) Age Factors Anti-Müllerian hormone Middle Aged medicine.disease Antral follicle Menopause Fertility Human Reproduction Renal disorder [NCEBP 12] biology.protein Female business Biomarkers Follow-Up Studies |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 96, 8, pp. 2532-9 Journal of Clinical Endocrinology and Metabolism, 96, 2532-9 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Item does not contain fulltext CONTEXT: It has been hypothesized that a fixed interval exists between age at natural sterility and age at menopause. Both events show considerable individual variability, with a range of 20 yr. Correct prediction of age at menopause could open avenues of individualized prevention of age-related infertility and other menopause-related conditions, like cardiovascular disease and breast carcinoma. OBJECTIVE: The aim of this study was to explore the ability of ovarian reserve tests to predict age at menopause. DESIGN AND SETTING: We conducted a long-term follow-up study at an academic hospital. PARTICIPANTS: A total of 257 normoovulatory women (age, 21-46 yr) were derived from three cohorts with highly comparable selection criteria. INTERVENTIONS: Anti-Mullerian hormone (AMH), antral follicle count, and FSH were assessed at time 1 (T1). At time 2 (T2), approximately 11 yr later, cycle status (strictly regular, menopausal transition, or postmenopause) and age at menopause were inventoried. MAIN OUTCOME MEASURES: Accuracy of the ovarian reserve tests in predicting time to menopause was assessed by Cox regression, and a nomogram was constructed for the relationship between age-specific AMH concentrations at T1 and age at menopause. RESULTS: A total of 48 (19%) women had reached postmenopause at T2. Age, AMH, and antral follicle count at T1 were significantly related with time to menopause (P < 0.001) and showed a good percentage of correct predictions (C-statistic, 0.87, 0.86, and 0.84, respectively). After adjusting for age, only AMH added to this prediction (C-statistic, 0.90). From the constructed nomogram, it appeared that the normal distribution of age at menopause will shift considerably, depending on the individual age-specific AMH level. CONCLUSIONS: AMH is highly predictive for timing of menopause. Using age and AMH, the age range in which menopause will subsequently occur can be individually calculated. |
| Databáze: | OpenAIRE |
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