[3H] Imipramine binding in brain samples from depressed suicides and controls: 5-HT uptake sites compared with sites defined by desmethylimipramine
| Autor: | Mohan Kanagasundaram, M. Rufus Crompton, Kevin M. Lawrence, Cornelius Katona, Roger W. Horton, Sandra Lowther |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Imipramine Serotonin medicine.medical_specialty Frontal cortex Adolescent Central nervous system Poison control Substantia nigra Tritium Radioligand Assay Cause of Death Internal medicine mental disorders medicine Humans Depression (differential diagnoses) Aged Depressive Disorder Binding Sites Chemistry Putamen Desipramine Brain Middle Aged Antidepressive Agents Frontal Lobe Substantia Nigra Suicide Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Endocrinology nervous system Anesthesia Female medicine.drug |
| Zdroj: | Journal of Affective Disorders. 47:105-112 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/s0165-0327(97)00126-2 |
| Popis: | Using desmethylimipramine (DMI) defined and Na+ dependent [3H]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake, in frontal cortex, putamen and substantia nigra of suicides with a firm retrospective diagnosis of depression and matched controls. No differences were seen between antidepressant-free suicides and controls, although [3H]imipramine binding sites were significantly lower in putamen of the subgroup of non-violent suicides. The number of DMI defined [3H]imipramine binding sites was also significantly lower in putamen of antidepressant-treated suicides. |
| Databáze: | OpenAIRE |
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