Structure of the spiroketal-macrolide ossamycin
| Autor: | Herbert A. Kirst, Jorge Rios Steiner, Jon S. Mynderse, Patrick J. Baker, James W. Martin, Jonathan W. Paschal, Emil B. Lobkovsky, Jon Clardy |
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| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
biology Molecular Structure Chemistry Stereochemistry Streptomycetaceae Spectrum Analysis Stereoisomerism Nanotechnology Antineoplastic Agents Ring (chemistry) biology.organism_classification Crystallography X-Ray Anti-Bacterial Agents Cytovaricin chemistry.chemical_compound Aglycone Drug Discovery Molecule Actinomycetales Macrolides Streptomyces hygroscopicus |
| Zdroj: | The Journal of antibiotics. 49(2) |
| ISSN: | 0021-8820 |
| Popis: | Ossamycin is a cytotoxic agent of undetermined structure that was originally isolated in 1965 from culture broths of Streptomyces hygroscopicus var. ossamyceticus. Its overall structure and relative stereochemistry have now been determined by single crystal X-ray diffraction studies. Absolute stereochemistry was established according to the previously determined configuration of its aminosaccharide constituent, ossamine. The aglycone of ossamycin possesses a 24-membered macrolide ring system onto which is incorporated both a 6,6-spiroketal and 5-membered hemiketal ring system. The overall three-dimensional structure possesses features in common with the related macrocyclic antibiotics dunaimycin, cytovaricin, and A82548A. |
| Databáze: | OpenAIRE |
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