Hormone-associated variation of the glycan microheterogeneity pattern of human sex steroid-binding protein (hSBP)
| Autor: | Hervé Degrelle, J. Tardivel-Lacombe |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Glycan Macromolecular Substances medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Stimulation Biology Biochemistry Endocrinology Polysaccharides Pregnancy Reference Values Sex Hormone-Binding Globulin Internal medicine Concanavalin A medicine Humans Molecular Biology Binding protein Sex Steroid-Binding Protein Cell Biology Serum concentration Kinetics Estrogen biology.protein Molecular Medicine Female Sex Hormone Binding Protein Immunoelectrophoresis Two-Dimensional Hormone |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 39:449-453 |
| ISSN: | 0960-0760 |
| DOI: | 10.1016/0960-0760(91)90237-y |
| Popis: | hSBP is a steroid-binding protein (human) whose serum concentration is increased by estrogens and decreased by androgens. This regulation is independent of a direct effect on the hSBP gene transcription. The purpose of this work was to study the glycan microheterogeneous composition of the mature protein under physiological estrogen stimulation, by means of crossed affinoimmunoelectrophoresis using concanavalin-A. In men hSBP always divided into 2 fractions, both retarded. In women hSBP showed two other components, still more retarded. An explanation for these differences is given and the role of the glycan moiety of hSBP is discussed. |
| Databáze: | OpenAIRE |
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