Sensory processing and P300 event-related potential correlates of stimulant response in children with attention-deficit/hyperactivity disorder: A critical review
| Autor: | Carol L. Wilkinson, Anne B. Arnett, Tara M Rutter, Virginia Peisch |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Sensory processing
medicine.medical_treatment Population Impulsivity Article 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Neurodevelopmental disorder Event-related potential Physiology (medical) medicine Humans Attention deficit hyperactivity disorder 0501 psychology and cognitive sciences Child education education.field_of_study business.industry 05 social sciences Brain medicine.disease Precision medicine Event-Related Potentials P300 Sensory Systems Stimulant Treatment Outcome Neurology Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Clin Neurophysiol |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2021.01.015 |
| Popis: | Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with considerable impairment in psychiatric and functional domains. Although stimulant medication can reduce core symptoms of inattention, hyperactivity, and impulsivity, a subgroup of patients does not respond to this intervention. A precision medicine approach has been proposed, whereby biomarkers are used to identify an effective treatment approach for a given individual. This review synthesizes the existing literature on event-related potential (ERP) correlates of stimulant response in children diagnosed with ADHD, with the goal of evaluating the potential for ERP to inform precision medicine care in this population. Forty-three articles were examined and results tentatively suggest that stimulant medications normalize the amplitude of the P300 component, and this is also associated with behavioral improvement. In contrast, results generally indicate that stimulants do not significantly alter early processing components, although there are some exceptions to this finding. Implications for research, theory, and clinical work are considered and concrete recommendations for future directions are provided. While recognizing limitations of existing literature (e.g., homogenous samples, variable methodologies), we conclude that ERP methods represent a promising approach for precision medicine care of patients with ADHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect