Association of corneal nerve fiber measures with cognitive function in dementia
| Autor: | Georgios Ponirakis, Ahmed Own, Anoop Sankaranarayanan, Rhia Tosino, Ioannis N. Petropoulos, Ashfaq Shuaib, Susan Osman, Ahmed Elsotouhy, Noushad Thodi, Shafi Khan, Navas Nadukkandiyil, Mani Chandran, Marwa Elorrabi, Adnan Khan, Essa Al-Sulaiti, Maryam Al Kuwari, Hoda Gad, Ziyad Mahfoud, Marwan Ramadan, Rayaz A. Malik, Hanadi Al Hamad, Priya V Gawhale, Maryam Alobaidi, Fatima Al‐Shibani, Hamad Almuhannadi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Corneal nerve Physical function Cornea 03 medical and health sciences 0302 clinical medicine Cognition Nerve Fibers Diabetic Neuropathies Ophthalmology mental disorders medicine Dementia Humans Amyotrophic lateral sclerosis Research Articles Aged Microscopy Confocal business.industry General Neuroscience Multiple sclerosis Confounding Parkinson Disease Middle Aged medicine.disease Peripheral 030104 developmental biology Female Neurology (clinical) business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Popis: | Objectives Corneal confocal microscopy (CCM) is a noninvasive ophthalmic technique that identifies corneal nerve degeneration in a range of peripheral neuropathies and in patients with multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. We sought to determine whether there is any association of corneal nerve fiber measures with cognitive function and functional independence in patients with MCI and dementia. Methods In this study, 76 nondiabetic participants with MCI (n = 30), dementia (n = 26), and healthy age‐matched controls (n = 20) underwent assessment of cognitive and physical function and CCM. Results There was a progressive reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) (P |
| Databáze: | OpenAIRE |
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