Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas
| Autor: | Werner Grote, Elisabeth Gödde, A. C. Feller, Annekathrin Himmler, Karl Lennert, Brigitte Schlegelberger |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Monosomy
Pathology medicine.medical_specialty Anaplastic Lymphoma Chronic lymphocytic leukemia Immunology Biochemistry Chromosome aberration hemic and lymphatic diseases medicine Humans Prolymphocytic leukemia Chromosome Aberrations business.industry Lymphoma Non-Hodgkin Lymphoma T-Cell Peripheral Cell Biology Hematology medicine.disease Peripheral T-cell lymphoma Lymphoma T-Cell Cutaneous Lymphoma Immunoblastic Lymphadenopathy embryonic structures business Trisomy |
| Zdroj: | Blood. 83:505-511 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v83.2.505.505 |
| Popis: | Cytogenetic studies on lymph node and skin biopsy specimens and peripheral blood in 104 patients with peripheral T-cell lymphomas (PTL) were compared with histopathologic diagnoses made according to the updated Kiel classification. Low-grade lymphomas presented normal metaphases more frequently than high-grade ones (P < .0001). This difference remained significant if cases with greater than 10% and greater than 50% normal metaphases in unstimulated cultures and in cultures stimulated by different mitogens were compared. On the other hand, high-grade lymphomas more often showed aberrant clones (P < .05), triploid to tetraploid clones (P < .0001), and complex clones with more than four chromosome changes (P < .01). Low-grade PTL showed consistent cytogenetic features. Clones with both inv(14)(q11q32.1) and trisomy 8q, mostly caused by i(8q)(q10), were found in all cases of T-cell chronic lymphocytic leukemia (T-CLL) and T-cell prolymphocytic leukemia (T-PLL). Trisomy 3 was observed only in angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)-type PTL, T-zone lymphoma, and lymphoepithelioid lymphoma. Moreover, the proportion of normal metaphases in these PTL was higher than in the other low-grade PTL (P < .01). On the contrary, T-CLL, T-PLL, and cutaneous T-cell lymphomas (CTCL) showed complex clones (P < .0001), duplications in 6p (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|