Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease
| Autor: | Marisa Flook, Lidia Frejo, Alvaro Gallego-Martinez, Eduardo Martin-Sanz, Marcos Rossi-Izquierdo, Juan Carlos Amor-Dorado, Andres Soto-Varela, Sofia Santos-Perez, Angel Batuecas-Caletrio, Juan Manuel Espinosa-Sanchez, Patricia Pérez-Carpena, Marta Martinez-Martinez, Ismael Aran, Jose Antonio Lopez-Escamez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine área bajo la curva humanos Basal (phylogenetics) susceptibilidad a enfermedades 0302 clinical medicine Diagnosis mediadores de la inflamación differential diagnosis Leukocytes IL-1 beta Immunology and Allergy Gene Regulatory Networks Vestibular Migraine Age of Onset mediana edad Original Research biología computacional anciano CCL3 enfermedad de Meniere Area under the curve Middle Aged adulto CXCL1 IL-1β trastornos migrañosos Area Under Curve Cytokines Female Differential diagnosis Disease Susceptibility Symptom Assessment Inflammation Mediators medicine.symptom redes génicas reguladoras lcsh:Immunologic diseases. Allergy Adult leucocitos Migraine Disorders estudios de casos y controles Immunology Peripheral blood mononuclear cell Proinflammatory cytokine Diagnosis Differential 03 medical and health sciences medicine Humans perfiles de expresión génica Meniere Disease Aged business.industry Gene Expression Profiling Computational Biology medicine.disease diagnóstico 030104 developmental biology Migraine Case-Control Studies Leukocytes Mononuclear citocinas evaluación de síntomas lcsh:RC581-607 business Biomarkers CCL22 Tinnitus 030215 immunology |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada Consejo Superior de Investigaciones Científicas (CSIC) Frontiers in Immunology Frontiers in Immunology, Vol 10 (2019) |
| DOI: | 10.3389/fimmu.2019.01229 |
| Popis: | Vestibular Migraine (VM) and Meniere's Disease (MD) are episodic vestibular syndromes defined by a set of associated symptoms such as tinnitus, hearing loss or migraine features during the attacks. Both conditions may show symptom overlap and there is no biological marker to distinguish them. Two subgroups of MD patients have been reported, according to their IL-1 beta profile. Therefore, considering the clinical similarity between VM and MD, we aimed to investigate the cytokine profile of MD and VM as a means to distinguish these patients. We have also carried out gene expression microarrays and measured the levels of 14 cytokines and 11 chemokines in 129 MD patients, 82 VM patients, and 66 healthy controls. Gene expression profile in peripheral blood mononuclear cells (PBMC) showed significant differences in MD patients with high and low basal levels of IL-1 beta and VM patients. MD patients with high basal levels of IL- 1 beta (MDH) had overall higher levels of cytokines/chemokines when compared to the other subsets. CCL4 levels were significantly different between MDH, MD with low basal levels of IL- 1 beta (MDL), VM and controls. Logistic regression identified IL- 1 beta, CCL3, CCL22, and CXCL1 levels as capable of differentiating VM patients from MD patients (area under the curve = 0.995), suggesting a high diagnostic value in patients with symptoms overlap. This work was supported by PI13/1242 and PI17/1644 Grant from ISCIII by FEDER Funds from the EU. Marisa Flook is funded by FI18/00228 from ISCIII. |
| Databáze: | OpenAIRE |
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