Insecticide resistance in dengue vectors from hotspots in Selangor, Malaysia

Autor: H. L. Lee, Rosilawati Rasli, Ruziyatul Aznieda Azmi, Mohd Zainuldin Taib, Nurulhusna Ab Hamid, Siti Futri Farahininajua Fikri, Nur Ayuni Nazarudin, Nazni Wasi Ahmad, Yoon Ling Cheong, Rusydi Najmuddin Norzali, Afiq Ahnaf Hafisool, Topek Omar, Khairul Asuad Muhamed, Nur Fadillah Hamdan, Harith Aswad Ismail, M. Khairuddin Che Ibrahim, Roziah Ali
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Insecticides
Viral Diseases
Veterinary medicine
Hydrolases
RC955-962
Disease Vectors
Mosquitoes
Biochemistry
Dengue Fever
Dengue fever
Dengue
Insecticide Resistance
chemistry.chemical_compound
Medical Conditions
0302 clinical medicine
Aedes
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Organic Compounds
Esterases
Eukaryota
Agriculture
Organophosphates
Enzymes
Insects
Chemistry
Infectious Diseases
Larva
Physical Sciences
Malathion
Female
Public aspects of medicine
RA1-1270
Agrochemicals
Research Article
Neglected Tropical Diseases
Ethers
medicine.drug
Aedes albopictus
Arthropoda
Infectious Disease Control
030231 tropical medicine
Mosquito Vectors
Aedes aegypti
Aedes Aegypti
Biology
03 medical and health sciences
parasitic diseases
medicine
Animals
Larvicide
Organic Chemistry
Organisms
Chemical Compounds
Malaysia
Public Health
Environmental and Occupational Health
Biology and Life Sciences
Proteins
Tropical Diseases
biology.organism_classification
medicine.disease
Invertebrates
Insect Vectors
Species Interactions
030104 developmental biology
Deltamethrin
chemistry
Enzymology
Zoology
Entomology
Permethrin
Zdroj: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009205 (2021)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
1935-2727
Popis: Background In Malaysia, dengue remains a top priority disease and usage of insecticides is the main method for dengue vector control. Limited baseline insecticide resistance data in dengue hotspots has prompted us to conduct this study. The present study reports the use of a map on the insecticide susceptibility status of Aedes aegypti and Aedes albopictus to provide a quick visualization and overview of the distribution of insecticide resistance. Method and results The insecticide resistance status of Aedes populations collected from 24 dengue hotspot areas from the period of December 2018 until June 2019 was proactively monitored using the World Health Organization standard protocol for adult and larval susceptibility testing was conducted, together with elucidation of the mechanisms involved in observed resistance. For resistance monitoring, susceptibility to three adulticides (permethrin, deltamethrin, and malathion) was tested, as well as susceptibility to the larvicide, temephos. Data showed significant resistance to both deltamethrin and permethrin (pyrethroid insecticides), and to malathion (organophosphate insecticide) in all sampled Aedes aegypti populations, while variable resistance patterns were found in the sampled Aedes albopictus populations. Temephos resistance was observed when larvae were tested using the diagnostic dosage of 0.012mg/L but not at the operational dosage of 1mg/L for both species. Conclusion The present study highlights evidence of a potential threat to the effectiveness of insecticides currently used in dengue vector control, and the urgent requirement for insecticide resistance management to be integrated into the National Dengue Control Program.
Author summary Insecticide resistance may threaten the efficacy of insecticides currently used in the dengue vector control program. These current findings reveal widespread insecticide resistance in Aedes aegypti and Aedes albopictus sampled from dengue hotspots. This screening provides comprehensive data on insecticide resistance to insecticides commonly used in dengue vector control programs. The mapping approach utilized in this present study facilitates easy visualization of the resistance distribution in dengue vectors across many dengue hotspots. Therefore, it could hence be beneficial to the Ministry of Health in managing the threat of resistance before it compromises current dengue vector control strategies.
Databáze: OpenAIRE
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