Red cell distribution width is a potential predictor of early relapse in polymyalgia rheumatica
| Autor: | P.P. Sainaghi, A R Pedrinelli, M G Cittone, Veronica Vassia, E Matino, Erika Zecca, Daniele Sola, Raffaella Landi, S Tonello, E Rizzi, E Boin, Roberta Pedrazzoli, Mario Pirisi, Daniele Soddu, Mattia Bellan |
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| Rok vydání: | 2021 |
| Předmět: |
Erythrocyte Indices
Male musculoskeletal diseases 030213 general clinical medicine medicine.medical_specialty Red cell distribution width Giant Cell Arteritis Early Relapse Disease Gastroenterology Polymyalgia rheumatica 03 medical and health sciences 0302 clinical medicine Rheumatology Recurrence Prednisone Internal medicine medicine Humans Retrospective Studies relapse Aged 80 and over 030203 arthritis & rheumatology Predictive marker business.industry biomarker Red blood cell distribution width Stepwise regression medicine.disease RC31-1245 Polymyalgia Rheumatica Medicine Biomarker (medicine) Female business medicine.drug |
| Zdroj: | Reumatismo, Vol 73, Iss 2 (2021) |
| ISSN: | 2240-2683 0048-7449 |
| DOI: | 10.4081/reumatismo.2021.1395 |
| Popis: | Red blood cell distribution width (RDW) has been studied as a prognostic biomarker for different chronic inflammatory diseases. In this paper we aim to evaluate its potential role in the prediction of early relapse in patients affected by polymyalgia rheumatica (PMR). We revised retrospectively clinical records of patients who received a diagnosis of PMR, according to 2012 ACR/EULAR classification criteria, for whom baseline clinical and laboratory data were available. The baseline RDW variation coefficient was correlated to the risk of relapse, in the first 6 months of the disease. We identified 44 patients [females 15 (34.0%)/males 29 (66.0%); median age 80 (72-83)], 9 of whom had an early relapse. These patients showed a larger median RDW than patients who did not relapse [13.7 (13.5-14.9)% vs 13.5 (12.7-14.2)%; p=0.04). The two groups were comparable for all the other clinical and laboratory parameters considered. Interestingly, patients in the higher half of the RDW distribution showed a shorter relapse-free survival (p |
| Databáze: | OpenAIRE |
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