Effect of High Ethanol Intake on Vascular Reactivity to Serotonin, Vasopressin and Acetylcholine in Normotensive Rats
| Autor: | Antonio M. Cabral, Elisardo C. Vasquez, J. G. P. Pires, Nazaré Souza Bissoli |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Vasopressin Alcohol Drinking Vasopressins Neuropeptide Hemodynamics In Vitro Techniques 030204 cardiovascular system & hematology Peptide hormone Biochemistry 03 medical and health sciences 0302 clinical medicine Internal medicine Bradycardia medicine Animals Rats Wistar Mesenteric arteries Dose-Response Relationship Drug business.industry Biochemistry (medical) Cell Biology General Medicine Acetylcholine Mesenteric Arteries Rats Vasodilation medicine.anatomical_structure Blood pressure Endocrinology Vasoconstriction 030220 oncology & carcinogenesis Hypertension business medicine.drug |
| Zdroj: | Journal of International Medical Research. 21:133-137 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006059302100303 |
| Popis: | Chronic ethanol administration causes hypertension and alterations of vascular reactivity in rats. In several models of hypertension, alterations of vascular reactivity are believed to be secondary to the sustained increase in blood pressure. The present study investigated the effects of serotonin (5-hydroxytryptamine [5-HT]), vasopressin and acetylcholine (ACh) in the isolated perfused mesenteric arteries from Wistar rats submitted to an 8-week course of chronic ethanol intake (8 g/kg day). No significant differences were observed in the dose – response curves with regard to: pressor effect of 0.04 — 10.0 nmole 5-HT; relaxant effect of 0.05 — 50.0 nmole ACh; or the pressor effects of two 1.5-nmole doses of vasopressin between control rats and ethanol-fed rats. These results suggest that modifications in arterial reactivity to endogenous vasoactive substances (observed in other studies involving more prolonged ethanol treatment in rats) may be, in part, secondary to the increase in blood pressure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|