What Is the Influence of Both Risk Donor and Risk Receiver on Simultaneous Pancreas-Kidney Transplantation?
| Autor: | M.J. Requena-Tapia, Javier Briceño-Delgado, Álvaro Arjona-Sánchez, J.M. Sánchez-Hidalgo, J. Ruiz Rabelo, A. Rodríguez-Benot, J.J. Salamanca-Bustos, J.P. Campos-Hernandez |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Urology 030209 endocrinology & metabolism Kaplan-Meier Estimate Cold Ischemia Time 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors Humans Medicine 030212 general & internal medicine Survival analysis Retrospective Studies Transplantation business.industry Graft Survival Retrospective cohort study Middle Aged Kidney Transplantation Survival Analysis Tissue Donors medicine.anatomical_structure Multivariate Analysis Female Surgery Graft survival Pancreas Transplantation business Pancreas Body mass index |
| Zdroj: | Transplantation Proceedings. 50:664-668 |
| ISSN: | 0041-1345 |
| Popis: | Some factors affect the pancreas of a marginal donor, and although their influence on graft survival has been determined, there is an increasing consensus to accept marginal organs in a controlled manner to increase the pool of organs. Certain factors related to the recipient have also been proposed as having negative influence on graft prognosis. The objective of this study was to analyze the influence of these factors on the results of our simultaneous pancreas-kidney (SPK) transplantation series.Retrospective analysis of 126 SPK transplants. Donors and recipients were stratified in an optimal group (2 expanded donor criteria) and a risk group (≥2 criteria). A pancreatic graft survival analysis was performed using a Kaplan-Meier test and log-rank test. Prognostic variables on graft survival were studied by Cox regression. Postoperative complications (graded by Clavien classification) were compared by χMedian survival of pancreas was 66 months, with no significant difference between groups (P.05). Multivariate analysis showed risk factors to be donor age, cold ischemia time, donor body mass index, receipt body mass index, and receipt panel-reactive antibody.In our series, the use of pancreatic grafts from donors with expanded criteria is safe and has increased the pool of grafts. Different variables, both donor and recipient, influence the survival of the pancreatic graft and should be taken into account in organ distribution systems. |
| Databáze: | OpenAIRE |
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