Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders

Autor:	Christian Labenz, Peter Galle, Jörn M. Schattenberg, Karel Kostev, Simon Johannes Gairing, Peter Robert Galle
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	medicine.medical_specialty Index date genetic structures liver cirrhosis behavioral disciplines and activities Article anxiety disorders portal vein thrombosis depression Internal medicine mental disorders Medicine Prospective cohort study Depression (differential diagnoses) business.industry Proportional hazards model Incidence (epidemiology) General Medicine medicine.disease Portal vein thrombosis Cohort Anxiety medicine.symptom business human activities psychological phenomena and processes
Zdroj:	Journal of Clinical Medicine; Volume 10; Issue 23; Pages: 5689 Journal of Clinical Medicine, Vol 10, Iss 5689, p 5689 (2021) Journal of Clinical Medicine
ISSN:	2077-0383
DOI:	10.3390/jcm10235689
Popis:	Portal vein thrombosis (PVT) is a severe disease that adversely affects patients’ well-being. Data on the influence of PVT on the occurrence of depression or anxiety disorders are lacking. This study aimed to explore the impact of PVT on the incidence of depression and anxiety disorders diagnoses in a large German primary care cohort over a ten-year period. Patients with PVT were matched to non-PVT individuals by age, sex, yearly consultation frequency, index year and comorbidities in a 1:5 ratio. The primary outcome of the study was the incidence of depression and anxiety disorders. The relationship between PVT and both depression and anxiety disorders was investigated using Cox regression models. We compared 547 patients with PVT with 2735 matched individuals without PVT. Within 5 years of the index date, 17.4% of patients with PVT and 9.3% of non-PVT individuals were diagnosed with depression (p < 0.001). Anxiety disorders were diagnosed in 5.5% and 3.0% of patients with PVT and non-PVT individuals, respectively (p = 0.002). On regression analyses, PVT was positively associated with incident depression (HR 2.01, 95% CI 1.53–2.64, p < 0.001) as well as anxiety disorders (HR 2.16, 95% CI 1.35–3.46, p = 0.001). Regarding depression, this association remained significant in women as well as in men. There was no association between PVT and the incidence of anxiety disorders in women. In conclusion, PVT is associated with the development of depression and anxiety disorders. However, further prospective studies are needed to confirm our findings before definitive recommendations can be made.
Databáze:	OpenAIRE
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