Vaspin, a compensatory mechanism against high glucose levels since birth?
| Autor: | Patricia Gerez-Martínez, Fernando J. Lavalle-González, Consuelo Treviño Garza, Cynthia M. Estrada Zúñiga, Citlalli E. Hernández-Rodríguez, Fernando Montes-Tapia, Manuel Enrique de la O-Cavazos |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male insulin medicine.medical_specialty medicine.medical_treatment Endocrinology Diabetes and Metabolism Adipokine Adipose tissue Gestational Age lcsh:Diseases of the endocrine glands. Clinical endocrinology Umbilical cord Endocrinology Pregnancy Internal medicine medicine Humans glucose Serpins Glycated Hemoglobin lcsh:RC648-665 business.industry Insulin Infant Newborn lcsh:RJ1-570 birth weight Gestational age lcsh:Pediatrics Fetal Blood Prognosis medicine.disease Diabetes Gestational Vaspin medicine.anatomical_structure Cord blood Infant Small for Gestational Age Pediatrics Perinatology and Child Health cord blood Small for gestational age Female Original Article business Biomarkers Follow-Up Studies Hormone |
| Zdroj: | JCRPE, Vol 11, Iss 2, Pp 125-131 (2019) Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5727 |
| Popis: | Objective Hormones produced by fat tissue, adipokines, produced during intrauterine life have recently been implicated in fetal growth. Vaspin is an adipokine expressed in visceral adipose tissue and has insulin-sensitizing effects. Elevated serum vaspin concentrations are associated with alterations in insulin sensitivity. We aimed to determine if vaspin concentrations in cord blood from healthy, term newborns differ among those born small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). A secondary objective was to determine whether an association existed between vaspin and anthropometric measurements, glucose and insulin levels in the newborn. Methods The study population included healthy term newborns, 30 subjects in the SGA, 12 in the AGA, and 34 in the LGA group. Anthropometry was documented in all subjects. Blood was taken from the umbilical cord vein from each child for later analysis for vaspin, insulin and glucose concentrations. Results Cord blood vaspin, insulin and glucose concentrations were not different between the three study groups. A negative correlation between vaspin and glucose concentrations was demonstrated in the whole cohort (r=-0.364, p=0.001). This correlation was also observed in the LGA group (r=-0.482, p=0.004). Glucose concentrations significantly predicted vaspin concentrations (r2=0.132, p=0.001). Conclusion We found a negative association between glucose and vaspin concentrations in umbilical cord blood. In addition there was a predictive association between blood glucose and resulting vaspin concentration, suggesting that vaspin can be used as a predictor of alterations in the insulin-glucose metabolism from birth. |
| Databáze: | OpenAIRE |
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