Most Enterobacter aerogenes Strains in France Belong to a Prevalent Clone
| Autor: | C. Bosi, Monique Malléa, Jean-Marie Pagès, A. Davin-Regli, Charléric Bornet, C. Bollet |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
clone (Java method) Imipenem Enterobacter Enterobacter aerogenes Polymerase Chain Reaction beta-Lactamases Microbiology Intergenic region Intensive care medicine Humans Demography Antibacterial agent biology Molecular epidemiology Enterobacteriaceae Infections Reproducibility of Results Bacteriology Laboratories Hospital biology.organism_classification Introns Random Amplified Polymorphic DNA Technique France Bacterial Outer Membrane Proteins Plasmids medicine.drug |
| Zdroj: | Journal of Clinical Microbiology. 37:2165-2169 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.37.7.2165-2169.1999 |
| Popis: | The aim of this study was to determine the distribution in France of the Enterobacter aerogenes prevalent clone isolated in the hospitals of the Marseille area (A. Davin-Regli, D. Monnet, P. Saux, C. Bosi, R. Charrel, A. Barthelemy, and C. Bollet, J. Clin. Microbiol. 34:1474–1480, 1996). A total of 123 E. aerogenes isolates were collected from 23 hospital laboratories and analyzed by random amplification of polymorphic DNA and enterobacterial repetitive intergenic consensus-PCR to determine their epidemiological relatedness. Molecular typing revealed that 21 of the 23 laboratories had isolated this prevalent clone harboring the plasmid encoding for extended-spectrum β-lactamase of the TEM-24 type. Most isolates were susceptible only to imipenem and gentamicin. Their dissemination seems to be clonal and was probably the result of the general use of broad-spectrum cephalosporins and quinolones. Four isolates showed an alteration of their outer membrane proteins, causing decrease of susceptibility to third-generation cephalosporins and imipenem and leading to the critical situation of having no alternative therapeutic. The large dissemination of the E. aerogenes prevalent clone probably results from its good adaptation to the antibiotics administered in France and the hospital environment, particularly in intensive care units. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|