Molecular Evolution and Subfunctionalization of Nkx2.1 in the Rainbow Trout
| Autor: | Yoshie Hidaka, Youji Uemae, Shigeyasu Tanaka, Masakazu Suzuki |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
endocrine system
animal structures animal diseases Thyroid Nuclear Factor 1 General Biochemistry Genetics and Molecular Biology Evolution Molecular History and Philosophy of Science Transcription (biology) Molecular evolution Animals Humans Tissue distribution Gene Phylogeny Genetics biology urogenital system General Neuroscience Nuclear Proteins Anatomy respiratory system biology.organism_classification Trout Organ Specificity Oncorhynchus mykiss Thyroid Follicular Cells Subfunctionalization Rainbow trout HeLa Cells Transcription Factors |
| Zdroj: | Annals of the New York Academy of Sciences. 1040:479-482 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1327.096 |
| Popis: | Because specification of duplicated genes is considered to be a major driving force for diversity and evolution, it is important to understand the function of the duplicated genes. In mammals, Nkx2.1 is essential for the differentiation of thyroid follicular cells and for the transcription of thyroid-specific genes. We have cloned four distinct Nkx2.1 cDNAs from the rainbow trout, Oncorhynchus mykiss. In the present article, we will characterize the trout Nkx2.1 mRNAs and show their tissue distribution, their transcriptional activities, and their expression during early development. |
| Databáze: | OpenAIRE |
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