Eradicating biofilm infections: an update on current and prospective approaches
| Autor: | Irina Afonina, Ronni A G da Silva, Kimberly A. Kline |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Multiple stages medicine.medical_specialty medicine.drug_class Antibiotics Biofilm Bacterial Infections biochemical phenomena metabolism and nutrition Biology Antimicrobial Microbiology Anti-Bacterial Agents Mini review Clinical Practice Infectious Diseases Antibiotic resistance Anti-Infective Agents Biofilms medicine Humans Prospective Studies Intensive care medicine |
| Zdroj: | Current Opinion in Microbiology. 63:117-125 |
| ISSN: | 1369-5274 |
| DOI: | 10.1016/j.mib.2021.07.001 |
| Popis: | Biofilm formation is a multifactorial process and often a multi-species endeavour that involves complex signalling networks, chemical gradients, bacterial adhesion, and production or acquisition of matrix components. Antibiotics remain the main choice when treating bacterial biofilm-associated infections despite their intrinsic tolerance to antimicrobials, and propensity for acquisition and rapid dissemination of antimicrobial resistance within the biofilm. Eliminating hard to treat biofilm-associated infections that are antibiotic resistant will demand a holistic and multi-faceted approach, targeting multiple stages of biofilm formation, many of which are already in development. This mini review will highlight the current approaches that are employed to treat bacterial biofilm infections and discuss new approaches in development that have promise to reach clinical practice. |
| Databáze: | OpenAIRE |
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