The influence of ethanol on superdisintegrants and on tablets disintegration
| Autor: | Hatim S. AlKhatib, Anaheed Blaibleh, Lorina Bisharat, Alberto Berardi, Suha Al Muhaissen, Marco Cespi, Julian Quodbach |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Calcium Phosphates
Chemistry Pharmaceutical Pharmaceutical Science Alcohol 02 engineering and technology 030226 pharmacology & pharmacy Dosage form Excipients 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Theophylline Food science Solubility Ethanol effect Croscarmellose sodium Ethanol Povidone Water Starch 021001 nanoscience & nanotechnology chemistry Carboxymethylcellulose Sodium Swelling medicine.symptom 0210 nano-technology medicine.drug Tablets |
| Zdroj: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 129 |
| ISSN: | 1879-0720 |
| Popis: | Disintegration of immediate release tablets originates from the volume expansion of disintegrants within the formulation. Here, we study the impact of ethanol on the disintegrant expansion and on tablets disintegration. The three most commonly used superdisintegrants, namely sodium starch glycolate (SSG), crospovidone (PVPP) and croscarmellose sodium (CCS) were investigated alone and incorporated in dicalcium phosphate and in drug-containing tablets. High (i.e. 40%), but not moderate (i.e. 10%), aqueous ethanol concentrations reduce the size expansion of the three disintegrants compared to water. This "ethanol effect" is the greatest for SSG, followed by CCS and then PVPP. Moreover, the presence of ethanol in the media can significantly influence the disintegration time of drug-containing tablets via affecting both the disintegrant action itself and the drug solubility. For example, the disintegration time of theophylline tablets containing SSG is 8.1-fold greater in 40% aqueous ethanol compared to water. Overall, this study brought to light the existence of a potentially significant interference of alcohol with the disintegration phenomenon, suggesting that the concomitant administration of tablets and intake of alcoholic beverages may affect, in some cases, tablets disintegration. More studies are now needed to verify the importance of the "ethanol effect" on disintegration of commercial dosage forms. Our findings also suggest that PVPP is the disintegrant that is the least affected by alcohol. |
| Databáze: | OpenAIRE |
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