Clinical and Pharmacokinetic Aspects of High Dose Oral Baclofen Therapy
| Autor: | Jesse M. Cedarbaum, Henn Kutt, Mindy L. Aisen, Mark A. Dietz, Peter Rossi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male 0301 basic medicine Drug Baclofen Multiple Sclerosis Dose medicine.drug_class media_common.quotation_subject Administration Oral Pilot Projects 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Humans Medicine Spasticity Spinal cord injury Spinal Cord Injuries Aged media_common Dose-Response Relationship Drug business.industry organic chemicals musculoskeletal neural and ocular physiology Muscle relaxant General Medicine Middle Aged medicine.disease Symptomatic relief body regions 030104 developmental biology nervous system chemistry Anesthesia Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of The American Paraplegia Society. 15:211-216 |
| ISSN: | 0195-2307 |
| Popis: | Baclofen is a centrally acting muscle relaxant used for treatment of spasticity. Some patients, to experience adequate symptomatic relief, require dosages of baclofen that significantly exceed the conventional 80 mg daily maximum advocated by the 1992 Physicians' Desk Reference. In this pilot study of baclofen kinetics and dynamics in eleven patients, the safety and efficacy of high dose baclofen was confirmed. The data suggest that the pharmacokinetics of high dose baclofen may vary from those described previously. Time-to-peak plasma levels and plasma half-lives were noted to be substantially longer than prior reports indicate. Baclofen blood levels were observed to rise gradually over time in some patients on a stable dosing regimen, probably a result of impaired renal clearance. These findings may indicate that a change in pattern of prescription is warranted and that a reliable and practical measurement of systemic baclofen levels has a useful role in clinical practice, particularly for the patient with neurogenic bladder and potential renal insufficiency. |
| Databáze: | OpenAIRE |
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