Association of peripapillary hyper-reflective ovoid masslike structures and disease duration in primary progressive multiple sclerosis
| Autor: | Katrin Giglhuber, Tania Kümpfel, Joachim Havla, Rebecca Wicklein, Bernhard Hemmer, Benjamin Knier, Josephine Wauschkuhn |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Disease duration Primary Progressive Multiple Sclerosis Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Multiple Sclerosis Relapsing-Remitting Internal medicine medicine Humans In patient 10. No inequality 030304 developmental biology 0303 health sciences Expanded Disability Status Scale business.industry Multiple sclerosis Multiple Sclerosis Chronic Progressive medicine.disease ddc Cross-Sectional Studies Neurology Cohort Ovoid Neurology (clinical) business 030217 neurology & neurosurgery Tomography Optical Coherence |
| Zdroj: | European journal of neurologyREFERENCES. 28(12) |
| ISSN: | 1468-1331 |
| Popis: | BACKGROUND AND PURPOSE Peripapillary hyper-reflective ovoid masslike structures (PHOMS) are a novel finding during retinal optical coherence tomography in patients with multiple sclerosis (MS). To date, there are no data on the occurrence of PHOMS in early MS. The aim of this study was to investigate the frequency of PHOMS in patients with first diagnosed early relapsing-remitting MS (RRMS) and to search for associations of PHOMS with disease patterns in different MS subtypes. METHODS This was a cross-sectional analysis in two different cohorts: cohort 1, consisting of early RRMS patients (n = 349); cohort 2, consisting of patients with primary progressive MS (PPMS) (n = 66) and RRMS (n = 65). RESULTS Peripapillary hyper-reflective ovoid masslike structures were detected in 18.3% of patients with early RRMS. The occurrence of PHOMS was not associated with age, disease duration and disability. Investigating clinical patterns and the occurrence of PHOMS (cohort 2), an association of PHOMS with higher Expanded Disability Status Scale measures (PHOMS 4.9, 3.7-6.1; no PHOMS 3.5, 3.0-5.3; p = 0.03) and longer disease durations (PHOMS 6.5 years, 1.9-11.0; no PHOMS 1.0 years, 0.0-4.0, p = 0.0007) was found in patients with PPMS but not RRMS. After p value adjustment, the disease duration appeared to be more relevant (β = 0.16, p = 0.06). CONCLUSION Peripapillary hyper-reflective ovoid masslike structures were found in 18% of patients with early MS. The presence of PHOMS might be associated with disease progression only in PPMS but not RRMS, suggesting that PHOMS might be embedded in neurodegenerative processes. |
| Databáze: | OpenAIRE |
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