Aspirin administration might accelerate the subsidence of periprosthetic joint infection
| Autor: | Chun Yu Chen, Wei Hsin Hsiang, Shan Wei Yang, Yi Ping Wei, Ju Chun Chien |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Prosthesis-Related Infections medicine.drug_class 030106 microbiology Population Antibiotics lcsh:Medicine Periprosthetic Article 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Internal medicine Infection control Medicine Humans lcsh:Science education Aged Aged 80 and over 030222 orthopedics education.field_of_study Aspirin Multidisciplinary Proportional hazards model business.industry lcsh:R Case-control study Middle Aged Anti-Bacterial Agents Treatment Outcome Case-Control Studies Multivariate Analysis Infectious diseases lcsh:Q Drug Therapy Combination Female Hip Prosthesis Bacterial infection business Knee Prosthesis medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Since the past decade, aspirin, a popular anti-inflammatory drug, has been increasingly studied for its potential antimicrobial and antibiofilm activity with promising results, but studies were limited to in vitro and in vivo investigations. Moreover, evidence concerning the beneficial effects of aspirin on the treatment of biofilm-related infections in real-world population is limited. Thus, this study aimed to investigate whether aspirin could promote infection control for patients with periprosthetic joint infections (PJIs). A single-center database was searched. Regular aspirin exposure was defined as a prescription of aspirin for > 6 months before diagnosis of PJIs and consecutive use during the PJI treatment course at a dose ≧ 100 mg/day. General data, treatment modalities, and recurrence status were collected from medical records by an independent orthopedic surgeon. From January 01, 2010, to February 17, 2019, 88 patients who met the PJI criteria were identified and included in this study. Of these patients, 12 were taking aspirin regularly during the infectious events. In the Cox proportional hazards model, multivariate analysis revealed that the aspirin group demonstrated significant benefit via superior resolution of PJIs (HR 2.200; 95% CI 1.018–4.757; p = 0.045). In this study, aspirin is beneficial for infection resolution when combined with the current standard of PJI treatment and conventional antibiotics in the management of PJIs. |
| Databáze: | OpenAIRE |
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