TAMEC: a new analogue of cyclomyrsinol diterpenes decreases anxiety- and depression-like behaviors in a mouse model of multiple sclerosis
| Autor: | Zeinab Yazdiniapoure, Ali-Akbar Salari, Syed Mustafa Ghanadian, Fatemeh Mami, Behzad Zolfaghari, Morteza Kosari-Nasab, Abdul Majid Ayatollahi, Mostafa Haji Molla Hoseini |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Elevated plus maze Encephalomyelitis Autoimmune Experimental Interleukin-1beta Anxiety Hippocampus Open field 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Hippocampus (mythology) Animals Depression (differential diagnoses) Psychotropic Drugs Molecular Structure Depression Tumor Necrosis Factor-alpha Multiple sclerosis Interleukin General Medicine medicine.disease Interleukin-10 Mice Inbred C57BL Disease Models Animal 030104 developmental biology Neurology Female Neurology (clinical) medicine.symptom Diterpenes Psychology 030217 neurology & neurosurgery Behavioural despair test Clinical psychology |
| Zdroj: | Neurological research. 39(12) |
| ISSN: | 1743-1328 |
| Popis: | Objectives There is a significant prevalence of affective disorders including depression and anxiety in people with multiple sclerosis (MS), resulting in reduced quality of life. Since the current treatments are not generally effective, further studies are needed to find appropriate drugs to alleviate anxiety and depression symptoms in these patients. Methods The effects of a new analog of cyclomyrsinol diterpenes (TAMEC) isolated from Euphorbia sogdiana on the anxiety (open field and elevated plus maze test) and depressive-like behaviors (sucrose preference test and forced swim test) in EAE-induced C57BL/6 mice (EAE; a mouse model of MS) were investigated. Hippocampal tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-10 levels were also measured by ELISA. Results The results indicated that TAMEC treatment reduced anxiety and depression-like behavior. This drug also decreased the levels of TNF-α and IL1β and increased IL-10 level in the hippocampus. Discussion Taken together, our findings demonstrate that the drug we used here can reduce anxiety and depression-like symptoms in EAE-induced mice. However, more studies are still needed to validate, expand, and generalize these data. |
| Databáze: | OpenAIRE |
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