Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration
| Autor: | Chui Ming Gemmy Cheung, Glenn Yiu, David Cunefare, Neha Khandelwal, Rupesh Agrawal, Vivian S. Vuong, Justin V Migacz, Sina Farsiu, Steven Tran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Aging genetic structures Vasodilator Agents lcsh:Medicine Vasodilation Neurodegenerative Eye chemistry.chemical_compound Macular Degeneration 0302 clinical medicine Vascularity 80 and over Macula Lutea Fluorescein Angiography lcsh:Science Tomography Aged 80 and over Multidisciplinary medicine.diagnostic_test Fluorescein angiography 3. Good health medicine.anatomical_structure cGMP-specific phosphodiesterase type 5 Biomedical Imaging Female medicine.symptom Tomography Optical Coherence medicine.medical_specialty Sildenafil Article Sildenafil Citrate 03 medical and health sciences Clinical Research Ophthalmology medicine Humans Eye Disease and Disorders of Vision Aged business.industry Choroid lcsh:R Retinal Vessels Retinal Macular degeneration Phosphodiesterase 5 Inhibitors medicine.disease eye diseases 030104 developmental biology chemistry Optical Coherence Case-Control Studies lcsh:Q sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific reports, vol 9, iss 1 Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Age-related macular degeneration (AMD) - the leading cause of vision loss in the elderly - share many risks factors as atherosclerosis, which exhibits loss of vascular compliance resulting from aging and oxidative stress. Here, we attempt to explore choroidal and retinal vascular compliance in patients with AMD by evaluating dynamic vascular changes using live ocular imaging following treatment with oral sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor and potent vasodilator. Enhanced-depth imaging optical coherence tomography (EDI-OCT) and OCT angiography (OCT-A) were performed on 46 eyes of 23 subjects, including 15 patients with non-exudative AMD in one eye and exudative AMD in the fellow eye, and 8 age-matched control subjects. Choroidal thickness, choroidal vascularity, and retinal vessel density were measured across the central macula at 1 and 3 hours after a 100 mg oral dose of sildenafil citrate. Baseline choroidal thickness was 172.1 ± 60.0 μm in non-exudative AMD eyes, 196.4 ± 89.8 μm in exudative AMD eyes, and 207.4 ± 77.7 μm in control eyes, with no difference between the 3 groups (P = 0.116). After sildenafil, choroidal thickness increased by 6.0% to 9.0% at 1 and 3 hours in all groups (P = 0.001–0.014). Eyes from older subjects were associated with choroidal thinning at baseline (P = 0.005) and showed less choroidal expansion at 1 hour and 3 hours after sildenafil (P = 0.001) regardless of AMD status (P = 0.666). The choroidal thickening appeared to be primarily attributed to expansion of the stroma rather than luminal component. Retinal vascular density remained unchanged after sildenafil in all 3 groups (P = 0.281–0.587). Together, our studies suggest that vascular response of the choroid to sildenafil decreases with age, but is not affected by the presence of non-exudative or exudative AMD, providing insight into changes in vessel compliance in aging and AMD. |
| Databáze: | OpenAIRE |
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