Hemolysis and antihemolysis induced by amino acid-based surfactants
| Autor: | Lourdes Sánchez, M. Rosa Infante, Montserrat Mitjans, Verónica Martínez, M. Pilar Vinardell |
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| Rok vydání: | 2007 |
| Předmět: |
Erythrocytes
Hypotonic hemolysis Arginine Toxicology Hemolysis Surface-Active Agents Pulmonary surfactant medicine Humans Lipid bilayer Amino acid-based surfactants Micelles chemistry.chemical_classification Dose-Response Relationship Drug Chemistry Lysine Erythrocyte Membrane Osmolar Concentration Cationic polymerization General Medicine Volume expansion medicine.disease Amino acid Red blood cell Membrane medicine.anatomical_structure Biochemistry Counterion Plasma membrane |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/j.toxlet.2007.01.003 |
| Popis: | 8 pages, 3 figures.-- PMID: 17293064 [PubMed].-- Printed version published on Mar 8, 2007. Surfactants have the special ability to interact with the lipid bilayer of cell membranes. The red blood cell is one of the most used cellular membrane models to study the mechanisms underlying surfactant-induced osmotic cell resistance. To increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of five lysine-derivative anionic and three arginine-derivative cationic amino acid-based surfactants on hypotonic hemolysis. Results showed two different antihemolytic behaviors among amino acid-based surfactants, both related to the maximal protective concentration. How the physico-chemical properties and structure of these compounds determine the protection against hypotonic hemolysis is discussed in detail. We found a good correlation between the CMC and the concentrations resulting in maximum protection against hypotonic hemolysis for the cationic surfactants, but no correlation for the anionic surfactants. In the case of lysine derivative surfactants, which only differ in their counterions, the counterion is implicated in the differences in the antihemolytic potency and the hemolytic activities of this. This research was supported by the Project PPQ- 2003-01834 from MCTE (Spain). Verónica Martínez and Lourdes Sánchez hold doctoral grants from Universitat de Barcelona (Spain) and Unidad Asociada-CSIC (Spain), respectively. The authors are grateful to Robin Rycroft for linguistic assistance. |
| Databáze: | OpenAIRE |
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