Psychometric testing of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) subscale in a longitudinal study of cancer patients treated with chemotherapy
| Autor: | Alexandre Chan, Kam Hung Wong, Simon Ching Lam, Janelle Yorke, Joseph S. K. Au, Yu Chung Li, Hui Lin Cheng, Alex Molassiotis, Raghav Sundar, Anthony Kwun To Leung, Violeta Lopez, Lorna K.P. Suen, Terrence Rong De Ng, Choi Wan Chan |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Longitudinal study GOG-Ntx Psychometrics Peripheral neuropathy FACT Antineoplastic Agents Gynecologic oncology lcsh:Computer applications to medicine. Medical informatics Confirmatory factor analysis 03 medical and health sciences 0302 clinical medicine Quality of life Cronbach's alpha Internal medicine Neoplasms Surveys and Questionnaires EORTC QLQ-CIPN20 medicine Humans Chemotherapy Longitudinal Studies Aged business.industry Minimal clinically important difference Research Public Health Environmental and Occupational Health Peripheral Nervous System Diseases Reproducibility of Results FACT/GOG-Ntx Common Terminology Criteria for Adverse Events Responsiveness General Medicine Middle Aged Convergent validity 030220 oncology & carcinogenesis Quality of Life Public Health and Health Services Health Policy & Services lcsh:R858-859.7 Female business 030217 neurology & neurosurgery |
| Zdroj: | Health and quality of life outcomes, vol 18, iss 1 Health and Quality of Life Outcomes Health and Quality of Life Outcomes, Vol 18, Iss 1, Pp 1-9 (2020) |
| Popis: | Background The aim of this study was to evaluate the psychometric properties of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group—Neurotoxicity (FACT/GOG-Ntx) subscale in a longitudinal study of cancer patients treated with chemotherapy. Methods Patients were assessed with the FACT/GOG-Ntx subscale, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Chemotherapy-Induced Peripheral Neuropathy Scale 20 (EORTC QLQ-CIPN20), National Cancer Institute -Common Terminology Criteria for Adverse Events (NCI-CTCAE), and light touch test using 10 g monofilament for up to ten assessment points from baseline (prior to initiation of first chemotherapy), after the end of each cycle (up to 6 cycles, 3 weeks per cycle), and at 6, 9, and 12 months after starting chemotherapy. Psychometric analyses included internal consistency reliability, convergent validity, factorial validity, sensitivity to change and responsiveness (minimal clinically important difference, MCID). Results Cronbach’s alpha coefficients of the FACT/GOG-Ntx subscale were 0.82–0.89 across assessment points. The subscale strongly correlated with the EORTC QLQ-CIPN20 (r = 0.79–0.93) but low-to-moderately correlated with the NCI-CTCAE sensory (rs = 0.23–0.45) and motor items (rs = 0.15–0.50) as well as the monofilament test (rs = 0.23–0.47). The hypothesized 4-factor structure of the FACT/GOG-Ntx subscale was not confirmed at assessment points (χ2/df = 2.26–8.50; all P r = 0.17–0.37). The MCIDs were between 1.38 and 3.68. Conclusion The FACT/GOG-Ntx subscale has satisfactory reliability, validity, sensitivity to change and responsiveness to evaluate CIPN in cancer patients. Future research is needed to explore the factorial structure of the FACT/GOG-Ntx subscale as the published four-factor structure was not supported in this study. |
| Databáze: | OpenAIRE |
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