Effect of exercise on intestinal tumour development in the male Fischer rat after exposure to azoxymethane
| Autor: | E B Thorling, Kim Overvad, N O Jacobsen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Epidemiology Fischer rat Exercise group Azoxymethane Physical exercise Colon mucosa Weight Gain Body Mass Index chemistry.chemical_compound Physical Conditioning Animal Internal medicine medicine Animals Treadmill business.industry Public Health Environmental and Occupational Health Lipids Rats Inbred F344 Rats Endocrinology Oncology Tumour development chemistry Colonic Neoplasms Lean body mass business |
| Zdroj: | European Journal of Cancer Prevention. 2:77-82 |
| ISSN: | 0959-8278 |
| DOI: | 10.1097/00008469-199301000-00012 |
| Popis: | Thirty-two male Fischer rats were exercised in a treadmill, 2 km daily on weekdays for 38 weeks, after three subcutaneous injections of azoxymethane, 15 mg/kg body weight. Randomly selected control animals were housed in regular 38 x 22 cm cages in groups of no more than three rats per cage. All rats were allowed free access to food and water. The exercising rats ate about 20% more than the sedentary rats, but gained less weight. Fat stores were considerably smaller in the exercised rats whereas the lean body mass and ash content were similar. After 38 weeks significantly fewer rats in the exercise group had developed neoplasia of the colon mucosa. |
| Databáze: | OpenAIRE |
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