Application of the New Oral Pancreatic Exocrine Function Test 'PFD' Test in Children—Normal Values in Children

Autor: Osamu Nose, Shinichiro Arashima, Hitoshi Taziri, Shogo Nagano, Tasuke Konno, Fumiko Itahashi, Hiroomi Kashii, Hiroshi Kai, Akio Kobayashi, Michio Koike, Hideo Kato, Yusaku Tazawa, Yuichiro Yamashiro, Keiichiro Sumiyama
Rok vydání: 1984
Předmět:
Zdroj: Pediatrics International. 26:82-90
ISSN: 1442-200X
1328-8067
DOI: 10.1111/j.1442-200x.1984.tb00603.x
Popis: The application of the PFD test, a newly developed technique for testing exocrine pancreatic function, was studied in infants and children. 1. This test is simple to perform and noninvasive so that it can be easily used in infants and children. 2. The test was performed on 125 normal children, and normal PFD-values i.e. > 1.2 x age + 48.5% in children over 2 years were established. For children under 2 years only reference PFD-values were obtained. The mean PFD-values in any age groups were lower than in normal adults. 3. Presumptive relationship between PFD recovery and urine volume or other factors was denied at least in normal children over 2 years and values affected only by exocrine pancreatic function (chymotrypsin activity) were obtained. 4. The PFD values correlate well with other parameters of exocrine pancreatic function in children with pancreatic insufficiency. As a result, the clinical value of the PFD test was demonstrated and the rationale for normal PFD-values in children was established. 5. It has also been shown that PFD values may be low when intestinal absorption, hepatic conjugation or renal excretion of PABA is impaired. 6. No adverse reactions to PFD test were noted except in one case of mild acute alcoholism which was presumably produced by ethyl alcohol used as the solvent. The precautions that should be exercised were also noted.
Databáze: OpenAIRE
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