Technical performance evaluation of a human brain PET/MRI system
| Autor: | Hans F. Wehrl, M. P. Lichy, Heinz Peter Schlemmer, Ralf Ladebeck, Bernd J. Pichler, Christian Michel, Claus D. Claussen, Armin Kolb, Vesna Sossi, Martin S. Judenhofer, Lars Eriksson, Matthias J. Schmand, Matthias Hofmann, Larry Byars |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Image processing Lutetium Signal-To-Noise Ratio Imaging phantom Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Neuroradiology Fluorodeoxyglucose Brain Mapping medicine.diagnostic_test Phantoms Imaging business.industry Silicates Brain Reproducibility of Results Equipment Design General Medicine Magnetic Resonance Imaging Positron emission tomography Positron-Emission Tomography Imaging technology Tomography Radiology business Nuclear medicine Emission computed tomography medicine.drug |
| Zdroj: | European Radiology. 22:1776-1788 |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | Technical performance evaluation of a human brain PET/MRI system. The magnetic field compatible positron emission tomography (PET) insert is based on avalanche photodiode (APD) arrays coupled with lutetium oxyorthosilicate (LSO) crystals and slip-fits into a slightly modified clinical 3-T MRI system. The mutual interference between the two imaging techniques was minimised by the careful design of the hardware to maintain the quality of the B 0 and B 1 field homogeneity. The signal-to-noise ratio (SNR) and the homogeneity of the MR images were minimally influenced by the presence of the PET. Measurements according to the Function Biomedical Informatics Research Network (FBIRN) protocol proved the combined system’s ability to perform functional MRI (fMRI). The performance of the PET insert was evaluated according to the National Electrical Manufacturers Association (NEMA) standard. The noise equivalent count rate (NEC) peaked at 30.7 × 103 counts/s at 7.3 kBq/mL. The point source sensitivity was greater than 7 %. The spatial resolution in the centre field of view was less than 3 mm. Patient data sets clearly revealed a noticeably good PET and MR image quality. PET and MRI phantom tests and first patient data exhibit the device’s potential for simultaneous multiparametric imaging. • Combination of PET and MRI is a new emerging imaging technology. • Evaluated brain PET/MRI enables uncompromised imaging performance. • PET/MRI aims to provide multiparametric imaging allowing acquisition of morphology and metabolism. |
| Databáze: | OpenAIRE |
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