Failure of oral E. coli O83 lipopolysaccharide to influence intestinal morphology and cell proliferation in rats: Short communication
| Autor: | Károly Baintner, György Illyés, Béla Kocsis, Krisztina Kovacs |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Lipopolysaccharide Administration Oral Biology Weight Gain medicine.disease_cause chemistry.chemical_compound Intestinal mucosa Oral administration Internal medicine Escherichia coli medicine Animals Intestinal Mucosa Cell Proliferation Gastrointestinal tract TUNEL assay General Veterinary Cell growth Epithelial Cells Rats Inbred Strains Small intestine Rats Intestines Endocrinology medicine.anatomical_structure chemistry Immunology Female |
| Zdroj: | Acta Veterinaria Hungarica. 56:1-3 |
| ISSN: | 1588-2705 0236-6290 |
| DOI: | 10.1556/avet.56.2008.1.1 |
| Popis: | It is known that bacterial lipopolysaccharide (LPS) is not absorbed from the gastrointestinal tract in significant quantities. However, the question remained whether oral LPS modified the structure or function of the gut. In the present experiment Escherichia coli O83 LPS was administered to growing rats in repeated oral doses of 400 mg/kg body weight (b. w.), every 8 h. After three days of treatment, morphometric and histochemical examinations of the small intestine did not show significant differences between treated and control rats. It is concluded that repeated oral administration of high doses of E. coli O83 LPS had no demonstrable effect on intestinal structure and cell proliferation in a rat model. |
| Databáze: | OpenAIRE |
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