The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases

Autor: Adam J. Mamelak, A. Tulli, Elliot Weiss, Daniel N. Sauder, Binghe Wang, Claudio Feliciani, Stephania La Morgia
Rok vydání: 2004
Předmět:
Zdroj: Journal of the American Academy of Dermatology. 50:657-675
ISSN: 0190-9622
DOI: 10.1016/j.jaad.2003.11.075
Popis: Interleukin 10 (IL-10) is a key cytokine produced by a multitude of immune effector cells and possesses distinct regulatory effects on immune functioning in the skin. In this article we report the current understanding of the immunobiology of IL-10 and identify the role of IL-10 in cutaneous infection as well as in autoimmune and neoplastic processes. We reviewed the literature to examine the function of IL-10 in different cutaneous disorders. IL-10 can influence and potentially treat T1/T2 differentiation, antigen-presenting cell functioning, antigen-presenting cell–mediated T-cell activation, and T-cell, B-cell, and mast cell growth and differentiation that is aberrant in various disease processes. The literature consensus is that the multitude of effects of IL-10 contribute to the pathogenesis of different skin disorders. In certain circumstances IL-10 could represent novel therapeutic approaches to treating cutaneous diseases. Learning objective At the conclusion of this learning activity, participants should be acquainted with the role of IL-10 in many infectious diseases, autoimmune skin disease, inflammatory processes, and malignancy. Its possible role in the resolution of various skin diseases should be better understood.
Databáze: OpenAIRE
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