Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms
| Autor: | Ludmila Gorunova, Lisbeth Haugom, Sverre Heim, Anne Mette Eibak, Francesca Micci, Ivar P. Gladhaug, Sven-Petter Haugvik |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty DNA Copy Number Variations Neuroendocrine tumors Biology Pathogenesis medicine Humans pancreas CGH Aged genomic imbalances Genome Human Chromosomes Human Pair 11 Cancer Karyotype Articles NEN General Medicine karyotyping Middle Aged medicine.disease Molecular medicine NET Pancreatic Neoplasms Pancreatic Neuroendocrine Neoplasm Neuroendocrine Tumors cell proliferation medicine.anatomical_structure Oncology Cytogenetic Analysis Female pancreatic neuroendocrine neoplasm Chromosome Deletion Pancreas Comparative genomic hybridization |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| Popis: | The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly understood. To gain insight into the genetic mechanisms underlying this tumor entity, we performed genome-wide screening of 16 surgical specimens from 15 patients with sporadic PNEN, combining G-band karyotyping and high resolution comparative genomic hybridization (HR-CGH). G-banding revealed abnormal karyotypes in 2 of 10 tumor samples analyzed. DNA copy number changes were detected in 13 samples, whereas three tumors showed a balanced genome. Gains were more frequent than losses in the nonfunctioning tumors (n=13). Common gains were scored at 5p12–13, 4q13–24, 5p15, 5q11–31, and 9q21–22. Common losses were scored at 11p11, 11p14–15, 11q23, 11p12–13, and 11q22. The average number of copy aberrations (ANCA index) was 12 for 13 nonfunctioning primary tumors, 4.8 for the nonfunctioning tumors with low Ki-67 (≥5%), 21.2 for the tumors with high Ki-67 ( |
| Databáze: | OpenAIRE |
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