Oral Cannabidiol Does Not Convert to Δ8-THC or Δ9-THC in Humans: A Pharmacokinetic Study in Healthy Subjects
| Autor: | Volnei José Tondo Filho, Sandra Aparecido Bernardo, Maria Eugênia Costa Queiroz, Jaime Eduardo Cecílio Hallak, José Alexandre de Souza Crippa, Carmem Maria Donaduzzi, Antonio Waldo Zuardi, Liberato Brum Junior, Bruna Miyazawa, Letícia Mello Rechia, Patrícia Moura da Rosa Zimmermann, Wagner Alex Jann Favreto, Francisco Silveira Guimarães, Silvane Guzzi, Alline C. Campos |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
business.industry Poison control Psychotomimetic PROTEÍNAS digestive system diseases surgical procedures operative Complementary and alternative medicine Pharmacokinetics Oral administration Delta-9-tetrahydrocannabinol medicine Pharmacology (medical) business Tetrahydrocannabinol Cannabidiol Corn oil Original Research medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2378-8763 2578-5125 |
| DOI: | 10.1089/can.2019.0024 |
| Popis: | Introduction: Recent studies have suggested that cannabidiol (CBD) could interconvert into Delta-8- and Delta-9- tetrahydrocannabinol. Materials and Methods: Thus, we tested the plasma samples of 120 healthy human subjects (60 male and 60 female), 60 in fasting and the other 60 under normal feeding conditions after acute administration of an oral solution containing CBD 300 mg. To do this, we developed a bioanalytical method to determine CBD and the presence of THC in plasma samples by Ultra-High Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Results: The results showed that THC was not detected in plasma after the administration of CBD, and those study participants did not present psychotomimetic effects. Conclusions: The findings presented here are consistent with previous evidence suggesting that the oral administration of CBD in a corn oil formulation is a safe route for the administration of the active substance without bioconversion to THC in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|