Allantoin as an independent marker associated with carotid intima-media thickness in subclinical atherosclerosis

Autor: K P Nascimento, Flavia Carla Meotti, I M Benseãor, Paulo A. Lotufo, M S Santana
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Physiology
030204 cardiovascular system & hematology
medicine.disease_cause
Carotid Intima-Media Thickness
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
General Pharmacology
Toxicology and Pharmaceutics
Allantoin
lcsh:QH301-705.5
Research Articles
lcsh:R5-920
biology
General Neuroscience
General Medicine
Middle Aged
Pulse pressure
Myeloperoxidase
lcsh:Medicine (General)
medicine.medical_specialty
Immunology
Biophysics
Ocean Engineering
03 medical and health sciences
Double-Blind Method
Internal medicine
Oxidation
medicine
Humans
Risk factor
Peroxidase
business.industry
Cell Biology
Atherosclerosis
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
Intima-media thickness
lcsh:Biology (General)
Subclinical atherosclerosis
Linear Models
biology.protein
Common carotid intima-media thickness
Uric acid
business
Biomarkers
Oxidative stress
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 51, Iss 8 (2018)
Brazilian Journal of Medical and Biological Research, Volume: 51, Issue: 8, Article number: e7543, Published: 18 JUN 2018
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.51 n.8 2018
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Popis: Allantoin is the main product of uric acid oxidation and was found to be augmented in atherosclerotic plaque in human autopsy and in animal models of atherosclerosis. Uric acid is abundant in human plasma and is prone to oxidation in inflammatory conditions such as atherosclerosis. In this study, we found a significant increase in plasma uric acid (P=0.002) and allantoin (P=0.025) in participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) that presented common carotid intima-media thickness (c-IMT) within the 75th percentile (c-IMT≥P75). Multiple linear regression showed an association of c-IMT with uric acid (β=0.0004, P=0.014) and allantoin (β=0.018, P=0.008). This association was independent of age, the traditional risk factor LDL/HDL ratio, and non-traditional risk factors: pulse pressure, neck circumference, and the inflammatory marker myeloperoxidase. The independent and strong association of allantoin with c-IMT shows that it might be a useful marker, along with other traditional risk factors, to evaluate an early stage of atherosclerosis.
Databáze: OpenAIRE
Externí odkaz: