Picornavirus RNA-dependent RNA polymerase
Autor: | Peter C. McMinn, Chee Choy Kok |
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Rok vydání: | 2009 |
Předmět: |
Picornavirus
Protein Conformation viruses Amino Acid Motifs RNA-dependent RNA polymerase Picornaviridae Viral quasispecies Virus Replication Biochemistry chemistry.chemical_compound Transcription (biology) RNA polymerase RNA polymerase I Animals Humans Polymerase Genetics Oligoribonucleotides Picornaviridae Infections Virulence biology Virus Assembly Cell Biology RNA-Dependent RNA Polymerase biology.organism_classification Virology Viral replication chemistry Organ Specificity Host-Pathogen Interactions Mutation biology.protein Crystallization |
Zdroj: | The International Journal of Biochemistry & Cell Biology. 41:498-502 |
ISSN: | 1357-2725 |
Popis: | Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined. This review discusses the structure and function of the poliovirus 3D polymerase. The high error rates of 3D polymerase result in high sequence diversity such that virus populations exist as quasispecies. This phenomenon is thought to facilitate survival of the virus population in complex environments. |
Databáze: | OpenAIRE |
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