The Prevalence of Extranodal Extension in Papillary Thyroid Cancer Based on the Size of the Metastatic Node: Adverse Histologic Features Are Not Limited to Larger Lymph Nodes
| Autor: | Lauren E. Yue, Alessandro Valentino, Margaret Brandwein-Weber, Rosalie A. Machado, Muhammad Qazi, Umut Ozbek, Juan C. Hernandez-Prera, Xulei Liu, Bruce M. Wenig, Meghan E. Rowe, Mark L. Urken |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Pathology and Forensic Medicine Papillary thyroid cancer Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Node (computer science) Prevalence medicine Humans Thyroid Neoplasms Child Lymph node Thyroid cancer Ene reaction Aged Retrospective Studies Aged 80 and over business.industry General Medicine Odds ratio Middle Aged medicine.disease Carcinoma Papillary Confidence interval medicine.anatomical_structure Thyroid Cancer Papillary Lymphatic Metastasis 030220 oncology & carcinogenesis Female Lymph business |
| Zdroj: | Endocrine Pathology. 29:80-85 |
| ISSN: | 1559-0097 1046-3976 |
| DOI: | 10.1007/s12022-018-9518-7 |
| Popis: | Extranodal extension (ENE) is a prognostic indicator of aggressiveness for papillary thyroid cancer (PTC). The association between the size of metastatic nodes and the prevalence of ENE has not been previously explored. However, there is a common belief that small lymph nodes with metastatic disease do not significantly impact patient outcome. This study investigates the relationship between the prevalence of ENE and the size of a positive lymph node. Linear dimensions and malignant histological characteristics of 979 metastatic lymph nodes from 152 thyroid cancer patients were retrospectively analyzed. Data was analyzed using chi-square tests and multilevel logistic regression modeling. ENE was present in 144 of 979 lymph nodes; the sizes of the involved lymph nodes ranged from 0.9 to 44 mm. ENE was identified in 7.8% of lymph nodes measuring ≤ 5 mm, 18.9% between 6 and 10 mm, 23.1% between 11 and 15 mm, 25.0% between 16 and 20 mm, and 14.0% between 21 and 25 mm in size. The association between node size and ENE status was significant (odds ratio (OR) = 1.07, confidence interval (CI) = [1.04, 1.11]). The size of the metastatic focus directly correlated with ENE (OR = 1.07, 95% CI = [1.07, 1.14], p value |
| Databáze: | OpenAIRE |
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