Quality of life changes and clinical outcomes in thyroid cancer patients undergoing radioiodine remnant ablation (RRA) with recombinant human TSH (rhTSH): a randomized controlled study
| Autor: | Anderson Loundou, Karine Baumstarck-Barrau, Josiane Vaillant, David Taïeb, S. Thomas, Olivier Mundler, C. De Micco, Bernard Conte-Devolx, Cécile Fortanier, Jf Henry, Bardia Farman-Ara, Pascal Auquier, M Cherenko, F. Sebag |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Randomization Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyrotropin law.invention Iodine Radioisotopes Endocrinology Thyroid-stimulating hormone Quality of life Randomized controlled trial law Internal medicine Humans Medicine Clinical significance Prospective Studies Thyroid Neoplasms Thyroid cancer business.industry Thyroid Thyroidectomy Middle Aged medicine.disease Recombinant Proteins humanities Treatment Outcome medicine.anatomical_structure Quality of Life Female business |
| Zdroj: | Clinical Endocrinology. 71:115-123 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2008.03424.x |
| Popis: | Summary Background Recombinant human TSH (rhTSH) has become the modality of choice for radioiodine remnant ablation (RRA) in low-risk thyroid cancer patients. Aims and methods The aims of the present prospective randomized study were to evaluate the impact of TSH stimulation procedure (hypothyroidism vs. rhTSH) on quality of life (QoL) of thyroid cancer patients undergoing RRA and to evaluate efficacy of both procedures. L-T4 was initiated in both groups after thyroidectomy. After randomization, L-T4 was discontinued in hypothyroid (hypo) group and continued in rhTSH group. A measure of 3·7 GBq of radioiodine was given to both groups. The functional assessment of chronic illness therapy-fatigue (FACIT-F) was administered from the early postoperative period to 9 months. Socio-demographic parameters, anxiety and depression scales were also evaluated (CES-D, BDI and Spielberger state-trait questionnaires). At 9 months, patients underwent an rhTSH stimulation test, diagnostic 131I whole body scan (dxWBS) and neck ultrasonography. Results A total of 74 patients were enrolled for the study. There was a significant decrease in QoL from baseline (t0) to t1 (RRA period) in the hypothyroid group with significant differences in FACIT-F TOI (P |
| Databáze: | OpenAIRE |
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