The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy
| Autor: | Shalina S. Ousman, Kathleen M. Hagen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chronic inflammatory demyelinating polyradiculoneuropathy
0301 basic medicine Aging medicine.medical_specialty Neurology Immunosenescence Immunology Review Disease lcsh:RC346-429 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Immune system Older patients medicine Animals Humans lcsh:Neurology. Diseases of the nervous system Immunity Cellular biology business.industry General Neuroscience Polyradiculoneuropathy medicine.disease 3. Good health 030104 developmental biology medicine.anatomical_structure Polyradiculoneuropathy Chronic Inflammatory Demyelinating Peripheral nervous system biology.protein Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021) Journal of Neuroinflammation |
| ISSN: | 1742-2094 |
| Popis: | Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of various autoimmune subtypes in which the peripheral nervous system (PNS) is attacked. CIDP can follow a relapsing-remitting or progressive course where the resultant demyelination caused by immune cells (e.g., T cells, macrophages) and antibodies can lead to disability in patients. Importantly, the age of CIDP patients has a role in their symptomology and specific variants have been associated with differing ages of onset. Furthermore, older patients have a decreased frequency of functional recovery after CIDP insult. This may be related to perturbations in immune cell populations that could exacerbate the disease with increasing age. In the present review, the immune profile of typical CIDP will be discussed followed by inferences into the potential role of relevant aging immune cell populations. Atypical variants will also be briefly reviewed followed by an examination of the available studies on the immunology underlying them. |
| Databáze: | OpenAIRE |
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