Dolominol a and B, two new neolignans from Dolomiaea souliei (Franch.) C.Shih
| Autor: | Guo-Wei Wang, Min Chen, Shen-Yue Qu, Jing-Xin Mao, Fan-Cheng Meng, Man Yi, Zhihua Liao, Mingxing Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Syringaresinol
010405 organic chemistry Stereochemistry Organic Chemistry Alcohol Ether Plant Science 01 natural sciences Biochemistry Cycloolivil 0104 chemical sciences Analytical Chemistry Dolomiaea souliei 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Medioresinol Octane |
| DOI: | 10.6084/m9.figshare.14216062 |
| Popis: | Two new neolignans, dolominol A (1) and dolominol B (2), together with 12 known lignans, erythro-(7S,8R)-guaiacyl-glycerol-β-O-4′-dihydroconiferyl ether (3), threo-(7R,8R)-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl)]-2-methoxyphenoxy}-1,3-propanediol (4), (-)-dihydrodehydrodiconiferyl alcohol (5), (-)-massoniresinol (6), vladinol D (7), syringaresinol (8), prinsepiol (9), medioresinol (10), (+)-pinoresinol (11), 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane (12), cycloolivil (13), isolariciresinol (14) were isolated from Dolomiaea souliei (Franch.) C.Shih. Their structures were determined by UV, CD, HR-ESI-TOFMS, 1 D and 2 D NMR experiments. Their hepatoprotective effect against LPS-induced L-02 cells injury was also studied. Result revealed that compound 4 showed best protective effect on LPS-induced L-02 cells. |
| Databáze: | OpenAIRE |
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