Risk of Tumor Transmission After Thoracic Allograft Transplantation from Adult Donors with Central Nervous System Neoplasm-A UNOS Database Study

Autor: Kendal M. Endicott, Fahad A. Alfares, Conor F. Hynes, Katrina Hammond-Jack, Karthik Ramakrishnan, Richard A. Jonas, David Zurakowski, Dilip S. Nath
Rok vydání: 2016
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
Allograft transplantation
medicine.medical_specialty
Pathology
Tissue and Organ Procurement
Databases
Factual
Central nervous system
030230 surgery
Logistic regression
Central Nervous System Neoplasms
Young Adult
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Risk Factors
Internal medicine
Outcome Assessment
Health Care
Humans
Medicine
Neoplasm
Registries
CNS TUMORS
Transplantation
business.industry
Transmission (medicine)
Incidence
Incidence (epidemiology)
Graft Survival
Database study
Middle Aged
Allografts
Prognosis
medicine.disease
Tissue Donors
United States
medicine.anatomical_structure
Cohort
Heart Transplantation
Female
030211 gastroenterology & hepatology
Surgery
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Lung Transplantation
Zdroj: The Journal of Heart and Lung Transplantation. 35:S290
ISSN: 1053-2498
DOI: 10.1016/j.healun.2016.01.827
Popis: Background We analyzed the UNOS database to better define the risk of transmission of central nervous system (CNS) tumors from donors to adult recipients of thoracic organs. Methods Data were procured from the Standard Transplant Analysis and Research dataset files. Donors with CNS tumors were identified, and recipients from these donors comprised the study group (Group I). The remaining recipients of organs from donors who did not have CNS tumors formed the control group (Group II). Incidence of recipient CNS tumors, donor-related malignancies, and overall survival were calculated and compared in addition to multivariable logistic regression. Results A cohort of 58 314 adult thoracic organ recipients were included, of which 337 received organs from donors who had documented CNS tumors (Group I). None of these recipients developed CNS tumors at a median follow-up of 72 months (IR: 30-130 months). Although overall mortality in terms of the percentage was higher in Group I than Group II (163/320=51% vs 22 123/52 691=42%), Kaplan-Meier curves indicate no significant difference in the time to death between the two groups (P=.92). Conclusions There is little risk of transmission of the common nonaggressive CNS tumors to recipients of thoracic organs.
Databáze: OpenAIRE
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