Bioinspired titanium coatings: self-assembly of collagen-alginate films for enhanced osseointegration
| Autor: | Guocheng Wang, Tanja Lüdtke, Marija Kosutic, Sergio Moya, Mihaela Delcea, Ricardo H. Pires, Danijela Gregurec |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Biomedical Engineering chemistry.chemical_element 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Osseointegration Coating medicine General Materials Science Fiber Composite material Layer by layer Osteoblast General Chemistry General Medicine Adhesion 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure chemistry Chemical engineering engineering Biopolymer 0210 nano-technology Titanium |
| Zdroj: | Journal of materials chemistry. B. 4(11) |
| ISSN: | 2050-7518 |
| Popis: | Achieving long term osseointegration is fundamental to the development of successful bone implants. A key aspect for improving long term osseointegration on titania surfaces is to gain control of nano- and microscale features. The so called biological approach is applied here to modify the surface of titania by coating it with a self-assembled and chemically crosslinked biopolymer film made of alginate and collagen. The biofilm coated titania closely mimics the bone extracellular matrix in bio-morphology and mechanical properties. Biofilms are prepared using the layer by layer technique combined with carbodiimide chemistry to achieve a stable and compact structure. Alginate–collagen coatings display fibrillar morphology with an apparent fiber diameter of ∼50 nm and lengths ranging from a few hundred nanometers to ∼3 μm, mimicking therefore the extracellular matrix of the bone in fiber length and extent. Osteoblast MC3T3-E1 cells showed enhanced adhesion on the coated surface compared to the bare titania and a superior biological activity of the alginate-terminated coating that interfaces the cells in biological fluids. |
| Databáze: | OpenAIRE |
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