Association of interleukin-10 gene haplotypes with Pseudomonas aeruginosa airway colonization in cystic fibrosis

Autor:	Fabio Cardinale, Antonio Manca, Lucio Armenio, Ombretta Silecchia, Francesco De Robertis, Riccardina Tesse, Teresa Santostasi, Angela Polizzi, L. Mappa
Rok vydání:	2008
Předmět:	Adult Male Pulmonary and Respiratory Medicine Adolescent Biology medicine.disease_cause Polymorphism Single Nucleotide Cystic fibrosis Microbiology Cohort Studies Young Adult medicine Humans Genetic Predisposition to Disease Pseudomonas Infections Colonization Pediatrics Perinatology and Child Health Child Promoter Regions Genetic Pathogen Pseudomonas aeruginosa Haplotype Gene polymorphism Promoter Middle Aged medicine.disease Interleukin-10 Interleukin 10 Haplotypes Child Preschool Pediatrics Perinatology and Child Health Immunology Female
Zdroj:	Journal of Cystic Fibrosis. 7:329-332
ISSN:	1569-1993
Popis:	We genotyped three polymorphisms of the promoter region of the interleukin-10 (IL-10) gene in 220 CF patients from the CF Center of Bari, and tested for an association between genetic variants of the cytokine and chronic airway colonization with Pseudomonas aeruginosa. We found that carriers of the high-IL-10-producing-GCC haplotype had significantly higher risk of chronic pulmonary infection with the pathogen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab551cd57c90dbb0e4628476efe619e https://doi.org/10.1016/j.jcf.2007.11.004 Zobrazit plný text záznamu Full Text from ScienceDirect